Optical Monitoring of Labile Zinc inside Metastatic Cells with Plasmonic Chemonanosensors
We report the development and characterization of an optical nanosensor for the detection of labile zinc in biological environments. The readout is based on surface-enhanced Raman scattering promoted by a Raman reporter conjugated to the inner plasmonic cavity of hollow silica nanocapsules. We quantify Zn<sup>2+</sup> by obtaining the ratio between a Zn<sup>2+</sup>-sensitive band and a Zn<sup>2+</sup>-insensitive band. The Raman reporter measures within the range from 10<sup>-5</sup> to 10<sup>-11</sup> M and exhibits a limit of detection of 10<sup>-11.72</sup> M. The nanosensor discriminates between intracellular and extracellular Zn<sup>2+</sup> concentrations.
Authors
- Pilar Rivera Gil (ORCID: https://orcid.org/0000-0002-6587-7538)
- Ting Zhou (ORCID: https://orcid.org/0000-0003-4098-4801)
- Rubén Vicente (ORCID: https://orcid.org/0000-0003-0401-4808)
Institutions
- Universitat Pompeu Fabra (ES)
Publication Details
- Journal
- ACS Omega
- Published
- 2024-10-03
- DOI
- https://doi.org/10.1021/acsomega.4c03631
- Citations
- 3
- Primary Topic
- Advanced biosensing and bioanalysis techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.70
Funders
- Ministerio de Ciencia, Innovación y Universidades
- China Scholarship Council
- Agència de Gestió d'Ajuts Universitaris i de Recerca
- Agencia Estatal de Investigación