Enantioselective 1,2-Carboamination of 1,3-Dienes with <i>N</i>-Hydroxyphthalimide (NHP) Esters Enabled by a Photoinduced Pd Catalysis
Herein, a photoinduced, Pd-catalyzed direct 1,2-carboamination of conjugated 1,3-dienes has been successfully achieved. Sequential regioselective C-C bond and enantioselective C-N bond formation allows rapid assembly of a wide range of value-added chiral allylic amines from readily available <i>N</i>-hydroxyphthalimide (NHP) esters and 1,3-dienes under mild conditions. This developed protocol further demonstrates the versatility and potency of the photoexcited Pd catalytic system with a bifunctional reagent in the streamlined difunctionalization of C═C bonds.
Authors
- Hao‐Yue Xiang (ORCID: https://orcid.org/0000-0002-7404-4247)
- Zhilin Liu (ORCID: https://orcid.org/0000-0002-7495-7994)
- Hua Yang (ORCID: https://orcid.org/0000-0002-5518-5255)
- Kai Chen (ORCID: https://orcid.org/0000-0003-1012-0383)
- Jia-Le Yan
Institutions
- Central South University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2024-10-03
- DOI
- https://doi.org/10.1021/acs.orglett.4c03080
- Citations
- 15
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 3.75
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hunan Province
- Fundamental Research Funds for Central Universities of the Central South University