The Updated Registry of Fast Myocardial Perfusion Imaging with Next-Generation SPECT (REFINE SPECT 2.0)

The Registry of Fast Myocardial Perfusion Imaging with Next-Generation SPECT (REFINE SPECT) has been expanded to include more patients and CT attenuation correction imaging. We present the design and initial results from the updated registry. <b>Methods:</b> The updated REFINE SPECT is a multicenter, international registry with clinical data and image files. SPECT images were processed by quantitative software and CT images by deep learning software detecting coronary artery calcium (CAC). Patients were followed for major adverse cardiovascular events (MACEs) (death, myocardial infarction, unstable angina, late revascularization). <b>Results:</b> The registry included scans from 45,252 patients from 13 centers (55.9% male, 64.7 ± 11.8 y). Correlating invasive coronary angiography was available for 3,786 (8.4%) patients. CT attenuation correction imaging was available for 13,405 patients. MACEs occurred in 6,514 (14.4%) patients during a median follow-up of 3.6 y (interquartile range, 2.5-4.8 y). Patients with a stress total perfusion deficit of 5% to less than 10% (unadjusted hazard ratio [HR], 2.42; 95% CI, 2.23-2.62) and a stress total perfusion deficit of at least 10% (unadjusted HR, 3.85; 95% CI, 3.56-4.16) were more likely to experience MACEs. Patients with a deep learning CAC score of 101-400 (unadjusted HR, 3.09; 95% CI, 2.57-3.72) and a CAC of more than 400 (unadjusted HR, 5.17; 95% CI, 4.41-6.05) were at increased risk of MACEs. <b>Conclusion:</b> The REFINE SPECT registry contains a comprehensive set of imaging and clinical variables. It will aid in understanding the value of SPECT myocardial perfusion imaging, leverage hybrid imaging, and facilitate validation of new artificial intelligence tools for improving prediction of adverse outcomes incorporating multimodality imaging.

Authors

Institutions

Publication Details

Journal
Journal of Nuclear Medicine
Published
2024-10-03
DOI
https://doi.org/10.2967/jnumed.124.268292
Citations
16
Primary Topic
Cardiac Imaging and Diagnostics
Type
article
Field-Weighted Citation Impact
6.47

Funders

Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

The Updated Registry of Fast Myocardial Perfusion Imaging with Next-Generation SPECT (REFINE SPECT 2.0)

Julian Halcox, Aakash Shanbhag, M. Timothy Hauser, Mônica Martins et al.
16 citations
Journal of Nuclear Medicine
Cardiac Imaging and Diagnostics
6.47
article

The Updated Registry of Fast Myocardial Perfusion Imaging with Next-Generation SPECT (REFINE SPECT 2.0)

Julian Halcox, Aakash Shanbhag, M. Timothy Hauser, Mônica Martins, Robert J.H. Miller, Albert J. Sinusas, Andrew J. Einstein, Sharmila Dorbala, Philipp A. Kaufmann, Damini Dey, Paul Kavanagh, Terrence D. Ruddy, Attila Feher, Wanda Acampa, Marcelo F. Di Carli, Daniel S. Berman, Mark A. Lemley, Tali Sharir, Piotr J. Slomka, Edward J. Miller, Giselle Ramirez, Valerie Builoff, Timothy M. Bateman, Joanna X. Liang, Mathews B. Fish
article en
16 citations

Abstract

The Registry of Fast Myocardial Perfusion Imaging with Next-Generation SPECT (REFINE SPECT) has been expanded to include more patients and CT attenuation correction imaging. We present the design and initial results from the updated registry. <b>Methods:</b> The updated REFINE SPECT is a multicenter, international registry with clinical data and image files. SPECT images were processed by quantitative software and CT images by deep learning software detecting coronary artery calcium (CAC). Patients were followed for major adverse cardiovascular events (MACEs) (death, myocardial infarction, unstable angina, late revascularization). <b>Results:</b> The registry included scans from 45,252 patients from 13 centers (55.9% male, 64.7 ± 11.8 y). Correlating invasive coronary angiography was available for 3,786 (8.4%) patients. CT attenuation correction imaging was available for 13,405 patients. MACEs occurred in 6,514 (14.4%) patients during a median follow-up of 3.6 y (interquartile range, 2.5-4.8 y). Patients with a stress total perfusion deficit of 5% to less than 10% (unadjusted hazard ratio [HR], 2.42; 95% CI, 2.23-2.62) and a stress total perfusion deficit of at least 10% (unadjusted HR, 3.85; 95% CI, 3.56-4.16) were more likely to experience MACEs. Patients with a deep learning CAC score of 101-400 (unadjusted HR, 3.09; 95% CI, 2.57-3.72) and a CAC of more than 400 (unadjusted HR, 5.17; 95% CI, 4.41-6.05) were at increased risk of MACEs. <b>Conclusion:</b> The REFINE SPECT registry contains a comprehensive set of imaging and clinical variables. It will aid in understanding the value of SPECT myocardial perfusion imaging, leverage hybrid imaging, and facilitate validation of new artificial intelligence tools for improving prediction of adverse outcomes incorporating multimodality imaging.

Journal of Nuclear MedicineVol. 65(11)
Ben-Gurion University of the Negev (IL), Providence Sacred Heart Medical Center (US), Cedars-Sinai Medical Center (US), Brigham and Women's Hospital (US), NewYork–Presbyterian Hospital (US), University of Ottawa (CA), University of Calgary (CA), Assuta Medical Center (IL), Yale University (US), Swansea University (GB), Sacred Heart Medical Center (US), University Hospital of Zurich (CH), Oklahoma Heart Hospital (US), Heart Imaging Technologies (United States) (US), Artificial Intelligence in Medicine (Canada) (CA), Libin Cardiovascular Institute of Alberta (CA), University of Naples Federico II (IT), Columbia University (US)
Pfizer, Sanofi, Advanced Accelerator Applications, Astellas Pharma, Bracco Diagnostics, National Institutes of Health, National Heart, Lung, and Blood Institute
Good health and well-being
Openalex Percentile: Top 3%
Cardiac Imaging and Diagnostics
6.47
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.