A Case of Clozapine-Induced Hepatotoxicity: Management Considerations and Future Direction

Clozapine is an atypical antipsychotic used for treatment-resistant schizophrenia. Its use is often limited due to its well-known association with a variety of side effects. Hepatotoxicity is a less common side effect and has been infrequently reported. Here, we present the case of a patient who developed abdominal discomfort and right upper quadrant pain after clozapine was initiated. Liver transaminases were found to be elevated and continued to rise despite cessation of another psychiatric medication more commonly associated with hepatotoxicity. Discontinuation of clozapine resulted in relief of symptoms and normalization of liver enzymes without any complications.