Construction of self-driving anti-αFR CAR-engineered NK cells based on IFN-γ and TNF-α synergistically induced high expression of CXCL10
This study confirmed that IFN-γ and TNF-α secreted by αFR-CAR-engineered NK cells can synergistically induce high expression of CXCL10 in ovarian cancer cells and constructed self-driving αFR-CAR-engineered NK cells that can break through migration barriers based on CXCL10, which may provide a new therapeutic weapon for ovarian cancer.
Authors
- Min He (ORCID: https://orcid.org/0000-0003-0361-8984)
- Xiang Xu (ORCID: https://orcid.org/0000-0002-1026-2210)
- Jing Xu (ORCID: https://orcid.org/0000-0003-1116-6631)
- Luoquan Ao
- Jianhua Yu (ORCID: https://orcid.org/0000-0002-0326-3223)
- Wei Guo (ORCID: https://orcid.org/0000-0002-3886-992X)
- Ping Yi (ORCID: https://orcid.org/0000-0002-4055-0459)
- Tao Liu (ORCID: https://orcid.org/0000-0002-4340-5767)
- Yanmin Xu
- Yu Yang (ORCID: https://orcid.org/0000-0002-4518-3299)
- Qian Cheng (ORCID: https://orcid.org/0000-0003-3621-5743)
- Xiang Ao (ORCID: https://orcid.org/0009-0007-2421-9735)
- Wei Xing
Institutions
- City Of Hope National Medical Center (US)
- Army Medical University (CN)
- Daping Hospital (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Southwest Hospital (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Neoplasia
- Published
- 2024-10-03
- DOI
- https://doi.org/10.1016/j.neo.2024.101065
- Citations
- 15
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 3.61
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China Stem Cell and Translational Research