Environment Responsive Peptide Dimers Bind and Stabilize dsRNA
In this study, we designed and synthesized novel dimeric peptides derived from TAV2b, that reversibly bind dsRNA.Interestingly, dimer 2'-2' increased the capability of RNA to withstand degradation in serum and promoted the cellular uptake of labeled siRNA.This study highlights how high affinity RNA ligands, can stabilize dsRNA and be equipped with environment-responsive binding properties, creating the basis for a significant advancement of dsRNA delivery strategies using peptides.
Authors
- Roland Brock (ORCID: https://orcid.org/0000-0003-1395-6127)
- Saskia Neubacher (ORCID: https://orcid.org/0000-0002-5744-226X)
- Marvin A. Albers
- Estel Collado Camps (ORCID: https://orcid.org/0000-0001-7424-4073)
- Tom N. Grossmann (ORCID: https://orcid.org/0000-0003-0179-4116)
- Jannik Paulus (ORCID: https://orcid.org/0000-0003-4359-6847)
- Niall M. McLoughlin (ORCID: https://orcid.org/0000-0001-8328-2506)
- Youri A. Ran
- Sven Henning
Publication Details
- Published
- 2024-09-20
- DOI
- https://doi.org/10.17952/37eps.2024.p1186
- Primary Topic
- RNA Interference and Gene Delivery
- Type
- article
- Field-Weighted Citation Impact
- 0.00