Inhibitory activity and proteolytic stability in human serum of peptide inhibitors of the Vascular Endothelial Growth Factor A165/Neuropilin-1 complex

Neuropilin-1 (NRP-1) is a cell surface receptor involved in a wide variety of signaling pathways, including physiological and pathological processes of angiogenesis.Its overexpression is associated with tumor aggressiveness and metastasis, which is observed, inter alia, in breast, pancreatic, prostate, colon cancer or brain tumors (e.g.gliomas) [1].One of the most important ligands of NRP-1 and the main mediators of angiogenesis is vascular endothelial growth factor A 165 (VEGF-A 165 ), which acts as a pro-angiogenic factor by interacting with NRP-1.