A combinatorial culture strategy to develop pseudomyxoma peritonei organoid models
The organoids we developed faithfully reproduce the key features of PMP disease and will allow us to understand the biology of PMP. With them, we will be able to identify key regulatory networks that support PMP progression, providing a platform for multilevel preclinical testing, identify novel diagnostic biomarkers, and generate novel targets for patient treatments.
Authors
- Massimo Milione (ORCID: https://orcid.org/0000-0002-1202-139X)
- Marcello Guagliò (ORCID: https://orcid.org/0000-0002-8194-9810)
- Jordi Martínez‐Quintanilla (ORCID: https://orcid.org/0000-0003-4279-2926)
- Patrick T. Caswell (ORCID: https://orcid.org/0000-0002-2633-2324)
- Tommaso Cavalleri (ORCID: https://orcid.org/0000-0002-8606-7382)
- Manuela Gariboldi (ORCID: https://orcid.org/0000-0001-8406-165X)
- Shigeki Kusamura (ORCID: https://orcid.org/0000-0002-3116-277X)
- Luca Varinelli (ORCID: https://orcid.org/0000-0002-0273-5807)
- Marcello Deraco (ORCID: https://orcid.org/0000-0003-4549-1395)
- Dario Baratti (ORCID: https://orcid.org/0000-0002-5442-2642)
- Federica Pisati
- Davide Battistessa
- Marzia Di Bella
Institutions
- Manchester Academic Health Science Centre (GB)
- Wellcome Centre for Cell-Matrix Research (GB)
- University of Manchester (GB)
- Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
- Vall d'Hebron Institute of Oncology (ES)
Publication Details
- Journal
- Journal of Surgical Oncology
- Published
- 2024-10-03
- DOI
- https://doi.org/10.1002/jso.27850
- Citations
- 2
- Primary Topic
- Intraperitoneal and Appendiceal Malignancies
- Type
- article
- Field-Weighted Citation Impact
- 1.15
Funders
- Associazione Italiana per la Ricerca sul Cancro