First detection and biological characterization of an avian metaavulavirus 8 isolated from a migratory swan goose in Qinghai Lake, Northwest China

Avian metaavulavirus 8 (AMAV-8), formerly known as avian paramyxovirus 8 (APMV-8), has been detected sporadically in wild birds worldwide since it was first identified in a Canadian goose in 1976. However, the presence of AMAV-8 in birds has never been reported in China. To understand the epidemiological situation of AMAV-8 and its ability to infect chickens, we conducted a surveillance study and in vivo analysis of the AMAV-8 isolate identified in total of 14,909 clinical samples collected from wild and domestic birds from 2014 to 2022 in China. However, in 2017, only one AMAV-8 virus (Y7) was successful isolated from the fresh droppings of a migratory swan goose in Qinghai Lake in Northwest China. Thereafter, we report the complete genome sequence of the Y7 strain with a genome length of 15,342 nucleotides and the Y7 isolate was genetically closely-related to wild bird-origin AMAV-8 viruses previously circulated in the United States, Japan, and Kazakhstan. Furthermore, AMAV-8 infections of one-day-old specific pathogen-free (SPF) chicks did not induce any clinical signs over the entire observation period but was associated with viral shedding for up to 8 days. Interestingly, although all birds infected with the Y7 strain seroconverted within the first week of infection, virus replication was only detected in the trachea but not in other tissues such as the brain, lung, or heart. Here, we report the complete genome, genetic and biological characterization, replication and pathogenicity analysis in vivo and first detection of AMAV-8 in China.

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Publication Details

Journal
Microbiology and Immunology
Published
2024-10-03
DOI
https://doi.org/10.1111/1348-0421.13175
Citations
2
Primary Topic
Virology and Viral Diseases
Type
article
Field-Weighted Citation Impact
0.77

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article

First detection and biological characterization of an avian metaavulavirus 8 isolated from a migratory swan goose in Qinghai Lake, Northwest China

Hongli Li, Claro N. Mingala, Bowen Zheng, Chao Gao et al.
2 citations
Microbiology and Immunology
Virology and Viral Diseases
0.77
article

First detection and biological characterization of an avian metaavulavirus 8 isolated from a migratory swan goose in Qinghai Lake, Northwest China

Hongli Li, Claro N. Mingala, Bowen Zheng, Chao Gao, Abdul Wajid, Hongjin Li, Aleksandar Dodovski, Tobias Stoeger, Yifei Liu, Huihui Wang, Xinxin Liu, Renfu Yin, Rui Luo, Weiwen Yan, Weiwei Chi, Sijie Wang, Xianwen Lin, Dmitry B. Andreychuk, Chuanrong Dong, Jianjun Chen, Y. Yin
article en
2 citations

Abstract

Avian metaavulavirus 8 (AMAV-8), formerly known as avian paramyxovirus 8 (APMV-8), has been detected sporadically in wild birds worldwide since it was first identified in a Canadian goose in 1976. However, the presence of AMAV-8 in birds has never been reported in China. To understand the epidemiological situation of AMAV-8 and its ability to infect chickens, we conducted a surveillance study and in vivo analysis of the AMAV-8 isolate identified in total of 14,909 clinical samples collected from wild and domestic birds from 2014 to 2022 in China. However, in 2017, only one AMAV-8 virus (Y7) was successful isolated from the fresh droppings of a migratory swan goose in Qinghai Lake in Northwest China. Thereafter, we report the complete genome sequence of the Y7 strain with a genome length of 15,342 nucleotides and the Y7 isolate was genetically closely-related to wild bird-origin AMAV-8 viruses previously circulated in the United States, Japan, and Kazakhstan. Furthermore, AMAV-8 infections of one-day-old specific pathogen-free (SPF) chicks did not induce any clinical signs over the entire observation period but was associated with viral shedding for up to 8 days. Interestingly, although all birds infected with the Y7 strain seroconverted within the first week of infection, virus replication was only detected in the trachea but not in other tissues such as the brain, lung, or heart. Here, we report the complete genome, genetic and biological characterization, replication and pathogenicity analysis in vivo and first detection of AMAV-8 in China.

Microbiology and ImmunologyVol. 68(12)
Shanxi Agricultural University (CN), Balochistan University of Information Technology, Engineering and Management Sciences (PK), Jilin University (CN), Chinese Academy of Sciences (CN), Central Luzon State University (PH), Helmholtz Zentrum München (DE), Wuhan Institute of Virology (CN), All-Russian Research Institute for Animal Health (RU), German Center for Lung Research (DE), Changchun University (CN), Ss. Cyril and Methodius University in Skopje (MK)
Natural Science Foundation of Jilin Province, Fundamental Research Funds for the Central Universities
Good health and well-being
Openalex Percentile: Top 25%
Virology and Viral Diseases
0.77
DOISourceOpenAlex
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