A 14-year longitudinal study of neurofilament light chain dynamics in premanifest and transitional Huntington’s disease
Our data suggest that (1) NfL longitudinal dynamics in premanifest/transitional HD are non-constant; rising faster in those closer to disease onset, and (2) NfL can identify individuals at risk of conversion to manifest disease and predict clinical trajectory, > 10 years from disease onset.
Authors
- Maura Malpetti (ORCID: https://orcid.org/0000-0001-8923-9656)
- Alpár S. Lázár (ORCID: https://orcid.org/0000-0003-3147-8229)
- Lennart R. B. Spindler
- Roger A. Barker (ORCID: https://orcid.org/0000-0001-8843-7730)
- Anna Goodman (ORCID: https://orcid.org/0000-0001-9995-6659)
- Natalia E. Owen (ORCID: https://orcid.org/0009-0008-0089-9120)
- Z J Voysey (ORCID: https://orcid.org/0000-0003-4916-6047)
- Clara Le Draoulec
- J. Adam Holbrook
Institutions
- University of East Anglia (GB)
- Wellcome/MRC Cambridge Stem Cell Institute (GB)
- University of Cambridge (GB)
Publication Details
- Journal
- Journal of Neurology
- Published
- 2024-10-03
- DOI
- https://doi.org/10.1007/s00415-024-12700-x
- Citations
- 9
- Primary Topic
- Genetic Neurodegenerative Diseases
- Type
- article
- Field-Weighted Citation Impact
- 2.41
Funders
- Wellcome Trust
- UK Research and Innovation
- Cure Parkinson's Trust
- Guarantors of Brain
- Alzheimer’s Research UK
- Medical Research Council
- NIHR Cambridge Biomedical Research Centre
- Cambridge Centre for Parkinson-Plus