A combined analysis of bulk RNA-seq and scRNA-seq was performed to investigate the molecular mechanisms associated with the occurrence of myocardial infarction
MI altered the transcriptomic landscapes of cardiac cells with increased expression of apoptotic genes. Moreover, the upregulation of macrophage apoptosis marker was confirmed within MI models. The presence of endothelial cell depletion and ferroptosis in MI has been demonstrated.
Authors
- Tao Tang (ORCID: https://orcid.org/0000-0001-7838-8525)
- Hengqing Zhu
- Jiangyong Yang (ORCID: https://orcid.org/0000-0001-9420-0684)
- Xie Chen (ORCID: https://orcid.org/0000-0002-4739-6247)
- Tian Li (ORCID: https://orcid.org/0000-0001-7810-7711)
- Yueting Wang (ORCID: https://orcid.org/0009-0003-0928-429X)
- Ling Huang (ORCID: https://orcid.org/0000-0002-5373-7394)
- Zheng Xie (ORCID: https://orcid.org/0009-0009-3787-3933)
- Yun Feng (ORCID: https://orcid.org/0000-0002-8998-1145)
- Jun Cao
- Weiling Lu
- Zhaohai Su
- Saichao Yang
- Rengui Jiang
- Huicong Xie
- Bilong Zhang
Institutions
- Ganzhou People's Hospital (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- BMC Genomics
- Published
- 2024-10-03
- DOI
- https://doi.org/10.1186/s12864-024-10813-1
- Citations
- 4
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 1.14
Funders
- Natural Science Foundation of Jiangxi Province