Impaired neutrophil-mediated cell death drives Ewing’s Sarcoma in the background of Down syndrome
In this context, the tumour underwent genome-wide near haploidisation resulting in a massive overexpression of pro-inflammatory cytokines. Recruitment of defective neutrophils fostered rapid evolution of this EWS.
Authors
- Caterina Parlato (ORCID: https://orcid.org/0000-0001-5304-3117)
- Francesca Priante
- Mauro Giulio Papotti (ORCID: https://orcid.org/0000-0002-2713-1700)
- Luca Bertero (ORCID: https://orcid.org/0000-0001-9887-7668)
- Elena Marini (ORCID: https://orcid.org/0000-0001-9793-3701)
- Katia Mareschi (ORCID: https://orcid.org/0000-0003-2889-0394)
- Anna Campello (ORCID: https://orcid.org/0000-0002-1274-4395)
- Elisa Tirtei (ORCID: https://orcid.org/0000-0003-4144-5957)
- Simonetta Guarrera (ORCID: https://orcid.org/0000-0003-4400-1817)
- Sebastian Dorin Asaftei (ORCID: https://orcid.org/0000-0002-3890-1686)
- Sarah Perrone
- Matteo Cereda (ORCID: https://orcid.org/0000-0003-1799-5537)
- Franca Fagioli (ORCID: https://orcid.org/0000-0002-9257-900X)
- Serena Peirone (ORCID: https://orcid.org/0000-0002-5195-7908)
Institutions
- University of Milan (IT)
- Italian institute for Genomic Medicine (IT)
- Ospedale Regina Margherita (IT)
- Candiolo Cancer Institute (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- University of Turin (IT)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2024-10-03
- DOI
- https://doi.org/10.3389/fonc.2024.1429833
- Citations
- 1
- Primary Topic
- Sarcoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.42
Funders
- Compagnia di San Paolo
- Ministero della Salute
- Fondazione Umberto Veronesi
- Associazione Italiana per la Ricerca sul Cancro