Spermidine attenuates chondrocyte inflammation and cellular pyroptosis through the AhR/NF-κB axis and the NLRP3/caspase-1/GSDMD pathway
Collectively, our findings propose SPD as a novel therapeutic approach for OA treatment, targeting the AhR pathway to counteract the disease's progression and highlighting the need for further clinical evaluation to fully establish its therapeutic utility.
Authors
- Xiaocheng Guo (ORCID: https://orcid.org/0000-0003-0541-0597)
- Xinyuan Feng (ORCID: https://orcid.org/0009-0007-2191-9314)
- He Zhang (ORCID: https://orcid.org/0000-0001-9198-6503)
- Yue Yang (ORCID: https://orcid.org/0000-0001-5530-9425)
- Lunhao Bai (ORCID: https://orcid.org/0000-0003-2381-0180)
Institutions
- China Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-10-02
- DOI
- https://doi.org/10.3389/fimmu.2024.1462777
- Citations
- 16
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 7.52
Funders
- National Natural Science Foundation of China
- China Medical University