IgG reactivity to different desmoglein-3 ectodomains in pemphigus vulgaris: novel panels for assessing disease severity
The level of autoantibodies against EC1 was not only correlated with the full ectodomain but also associated with higher disease severity and active disease phase. This study indicates that a detailed autoantibody profile against Dsg3 ectodomains could serve as a marker for PV severity and activity which may potentially enhance early treatment initiation.
Authors
- Alireza Gholami (ORCID: https://orcid.org/0000-0003-0706-2821)
- Maryam Daneshpazhooh (ORCID: https://orcid.org/0000-0003-1020-8895)
- Soheil Tavakolpour (ORCID: https://orcid.org/0000-0002-6765-8830)
- Hamidreza Mahmoudi (ORCID: https://orcid.org/0000-0002-1890-1005)
- Zahra Noormohammadi (ORCID: https://orcid.org/0000-0003-3890-9001)
Institutions
- Pasteur Institute of Iran (IR)
- Islamic Azad University, Science and Research Branch (IR)
- Razi Hospital (IR)
- Tehran University of Medical Sciences (IR)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-10-02
- DOI
- https://doi.org/10.3389/fimmu.2024.1469937
- Citations
- 2
- Primary Topic
- Autoimmune Bullous Skin Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.85