Angiotensin 1 peptide-conjugated CdSe/ZnS quantum dots for cardiac-specific hydrogen sulfide targeted therapy in myocardial ischemia-reperfusion injury
This study demonstrates that AT1 peptide-conjugated QDs can effectively deliver CSE plasmids to the heart, providing significant protection against I/R injury through enhanced localized H<sub>2</sub>S production. This approach offers a promising, targeted, and side-effect-free therapy for myocardial I/R injury, with potential for clinical translation.
Authors
- Qixia Jiang (ORCID: https://orcid.org/0000-0002-0897-3865)
- Jian Xiao
- Pei Wang (ORCID: https://orcid.org/0000-0002-1650-3353)
- Yue Yu (ORCID: https://orcid.org/0000-0002-0807-8713)
- Qing Wang (ORCID: https://orcid.org/0000-0001-8441-1912)
- Xiaofei Xue (ORCID: https://orcid.org/0000-0003-4092-6417)
- Jun Wang (ORCID: https://orcid.org/0000-0002-6278-0677)
Institutions
- Second Military Medical University (CN)
- Shanghai Jiao Tong University (CN)
- Shanghai Chest Hospital (CN)
- Shanghai Changzheng Hospital (CN)
- Tongren Hospital (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-10-02
- DOI
- https://doi.org/10.3389/fphar.2024.1435282
- Citations
- 8
- Primary Topic
- Sulfur Compounds in Biology
- Type
- article
- Field-Weighted Citation Impact
- 2.36
Funders
- Shanghai Municipal Health Commission
- National Natural Science Foundation of China