Salidroside may target PPARα to exert preventive and therapeutic activities on NASH
Our findings revealed that SDS could regulate liver autophagy and apoptosis, regulating both innate immunity and adaptive immunity and alleviating inflammation in NASH prevention and therapy via the PPAR pathway, suggesting that SDS could be a potential anti-NASH drug in the future.
Authors
- Baozhen Qu
- Yongning Xin (ORCID: https://orcid.org/0000-0002-3692-7655)
- Shousheng Liu (ORCID: https://orcid.org/0000-0002-2613-3237)
- Linlin Lu (ORCID: https://orcid.org/0000-0002-2062-4887)
- Xueru Chu
Institutions
- Qingdao University (CN)
- Affiliated Hospital of Qingdao University (CN)
- Qingdao Municipal Hospital (CN)
- Ocean University of China (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-10-02
- DOI
- https://doi.org/10.3389/fphar.2024.1433076
- Citations
- 4
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.55
Funders
- National Natural Science Foundation of China