Chebulinic acid isolated from aqueous extracts of Terminalia chebula Retz inhibits Helicobacter pylori infection by potential binding to Cag A protein and regulating adhesion
Overall, our findings suggest that chebulinic acid acts as an anti-adhesive agent, disrupting the adhesion of HP to host cells, which is a critical step in HP infection. It also suppresses the Cag A protein. These results highlight the potential of chebulinic acid against HP infections.
Authors
- Hengrui Liu (ORCID: https://orcid.org/0000-0002-5369-3926)
- Qingchang Chen (ORCID: https://orcid.org/0000-0001-5019-9087)
- Ling Ou (ORCID: https://orcid.org/0000-0002-4437-6427)
- Yajie Hao (ORCID: https://orcid.org/0000-0001-7087-7666)
- Meicun Yao (ORCID: https://orcid.org/0000-0002-4372-6528)
- Zhong Feng (ORCID: https://orcid.org/0000-0001-6522-859X)
- Qingwei Li (ORCID: https://orcid.org/0000-0001-5802-365X)
- Guimin Zhang (ORCID: https://orcid.org/0000-0001-7937-0917)
- Ruixia Wei
- Zhixiang Zhu (ORCID: https://orcid.org/0000-0002-7476-309X)
Institutions
- Sun Yat-sen University (CN)
- Jinan University (CN)
- National University of Singapore (SG)
- Tianjin Conservatory of Music (CN)
- Luye Pharma (China) (CN)
- Shandong Academy of Pharmaceutical Sciences (CN)
- Ocean University of China (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2024-10-02
- DOI
- https://doi.org/10.3389/fmicb.2024.1416794
- Citations
- 40
- Primary Topic
- Helicobacter pylori-related gastroenterology studies
- Type
- article
- Field-Weighted Citation Impact
- 22.91
Funders
- National Natural Science Foundation of China