Comparing single- and multi-post labeling delays for the measurements of resting cerebral and hippocampal blood flow for cerebrovascular testing in midlife adults
Our single-PLD pCASL-MOD protocol reliably measured CBF and hippocampal CBF at rest given the significant correlation with the multi-PLD pCASL-HCP protocol. Despite the lower magnitude relative to pCASL-HCP, we recommend using our pCASL-MOD protocol for CVR testing in which an exact estimate of CBF is not required such as the assessment of relative change in CBF to hypercapnia.
Authors
- Mary Kramer (ORCID: https://orcid.org/0000-0003-1305-9821)
- Christopher R. Martens (ORCID: https://orcid.org/0000-0003-0578-2948)
- Alexander Cerjanic (ORCID: https://orcid.org/0000-0002-3099-2392)
- Faria Sanjana (ORCID: https://orcid.org/0000-0001-6529-6680)
- Curtis L. Johnson (ORCID: https://orcid.org/0000-0002-7760-131X)
- Kevin Decker (ORCID: https://orcid.org/0000-0001-6595-0072)
- Nick Rizzi
Institutions
- Massachusetts General Hospital (US)
- University of Delaware (US)
Publication Details
- Journal
- Frontiers in Physiology
- Published
- 2024-10-02
- DOI
- https://doi.org/10.3389/fphys.2024.1437973
- Primary Topic
- Advanced MRI Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Institute of General Medical Sciences