Synergistic effects of peripheral GABA and GABA-transaminase inhibitory drugs on food intake control and weight loss in high-fat diet-induced obese mice
Combining dietary GABA with GABA-degradation inhibitory drugs effectively suppresses food intake and promotes weight loss in obese mice, primarily through increased plasma GABA availability. These findings may advance the development of food intake-controlling strategies for obesity management.
Authors
- Maesaya Chartkul
- Thanutchaporn Kumrungsee (ORCID: https://orcid.org/0000-0002-6196-5186)
- Tomoka Nagao
- Jason Braga
- Masubon Thongngam
- Siyi Chen (ORCID: https://orcid.org/0000-0003-1844-5860)
- Noriyuki Yanaka
Institutions
- Hiroshima University (JP)
- Kasetsart University (TH)
- Prapokklao Hospital (TH)
- Cavite State University (PH)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-10-02
- DOI
- https://doi.org/10.3389/fphar.2024.1487585
- Citations
- 7
- Primary Topic
- GABA and Rice Research
- Type
- article
- Field-Weighted Citation Impact
- 4.20
Funders
- Ministry of Education, Culture, Sports, Science and Technology
- Tojuro Iijima Foundation for Food Science and Technology