Lenticulostriatal Ischemia Shows Relevant SSTR Expression on PET/CT Imaging Using the Novel SSTR-Targeting Peptide 18F-SiTATE
A 64-year-old woman with meningioma presented with left-sided lenticulostriatal ischemia following craniotomy and debulking of a sphenoid wing meningioma. For subsequent radiotherapy planning, an SSTR-targeted PET/CT using the novel ligand 18 F-SiTATE was performed 2.5 months thereafter. The meningioma remnants showed transosseous, intrasellar, and perivascular extension around the internal carotid artery with strong SSTR expression. Moreover, there was focal 18 F-SiTATE uptake in the left caudate and corresponding contrast enhancement due to postischemic blood-brain barrier disruption and reactive SSTR expression. Therefore, increased cortical or subcortical SSTR PET signal may be related to ischemic changes even in the subacute stage after initial stroke.
Authors
- Lena M. Unterrainer
- Peter Bartenstein (ORCID: https://orcid.org/0009-0005-0734-4994)
- Claus Belka (ORCID: https://orcid.org/0000-0002-1287-7825)
- Christian Schichor (ORCID: https://orcid.org/0000-0001-6684-3578)
- Michael Winkelmann (ORCID: https://orcid.org/0000-0003-4655-7341)
- Nathalie L. Albert (ORCID: https://orcid.org/0000-0003-0953-7624)
- Carmen Wängler (ORCID: https://orcid.org/0000-0003-1161-8669)
- Ralf Schirrmacher (ORCID: https://orcid.org/0000-0002-7098-3036)
- Marcus Unterrainer (ORCID: https://orcid.org/0000-0002-8238-1198)
- Wolfgang G. Kunz (ORCID: https://orcid.org/0000-0002-5021-1952)
- Klaus Jurkschat (ORCID: https://orcid.org/0000-0001-9930-858X)
- Björn Wängler (ORCID: https://orcid.org/0000-0003-3877-5576)
- Simon Lindner (ORCID: https://orcid.org/0009-0007-4379-4436)
- Sophie C. Kunte (ORCID: https://orcid.org/0009-0003-3175-952X)
Institutions
- University of Alberta (CA)
- TU Dortmund University (DE)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- LMU Klinikum (DE)
- German Centre for Cardiovascular Research (DE)
- Molecular Theranostics (United States) (US)
- University Medical Centre Mannheim (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Clinical Nuclear Medicine
- Published
- 2024-10-02
- DOI
- https://doi.org/10.1097/rlu.0000000000005482
- Citations
- 1
- Primary Topic
- Meningioma and schwannoma management
- Type
- article
- Field-Weighted Citation Impact
- 0.39