The causality between rheumatoid arthritis and postural deformities: bidirectional Mendelian randomization study and mediation analysis
These findings indicate a potential causal association between genetically predicted RA and both hallux valgus and flat foot. Furthermore, hallux valgus serves as a mediator in the pathway from RA to flat foot. This underscores the importance of early screening and preventive treatment of foot deformities in RA patients. Further research is necessary to determine the applicability of these findings in non-European populations.
Authors
- Piqian Zhao
- Ya Wen (ORCID: https://orcid.org/0000-0001-8621-8016)
- Zhe Chen (ORCID: https://orcid.org/0000-0003-3619-8381)
- Liangyuan Wen
- Zijie Pei
- Hongtao Zhang
Institutions
- Capital Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
- Soochow University (CN)
- First Affiliated Hospital of Soochow University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-10-03
- DOI
- https://doi.org/10.3389/fimmu.2024.1453685
- Citations
- 1
- Primary Topic
- Rheumatoid Arthritis Research and Therapies
- Type
- article
- Field-Weighted Citation Impact
- 0.47