IVIG response in pediatric acute-onset neuropsychiatric syndrome correlates with reduction in pro-inflammatory monocytes and neuropsychiatric measures
The results of this study suggest that active PANS is associated with a pro-inflammatory state. This pro-inflammatory profile and psychometric scores improved following IVIG treatment. Future work will aim to further elucidate the roles of innate and adaptive immune responses in PANS and the regulatory mechanism(s) of IVIG in PANS treatment.
Authors
- Melinda Heffron
- Elizabeth Mellins (ORCID: https://orcid.org/0000-0003-2577-139X)
- Shamma S. Rahman (ORCID: https://orcid.org/0000-0003-2588-4466)
- Jennifer Frankovich (ORCID: https://orcid.org/0000-0001-7356-5617)
- Huub T. C. Kreuwel
- Isaac Melamed (ORCID: https://orcid.org/0000-0003-0094-9091)
- Heather Pein
Institutions
- IMMUNOe Research Center (US)
- Octapharma (United States) (US)
- Stanford University (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-10-03
- DOI
- https://doi.org/10.3389/fimmu.2024.1383973
- Citations
- 8
- Primary Topic
- Obsessive-Compulsive Spectrum Disorders
- Type
- article
- Field-Weighted Citation Impact
- 5.11