Lats-IN-1 protects cardiac function and promotes regeneration after myocardial infarction by targeting the hippo pathway
By modulating the Hippo pathway and reducing apoptosis markers, Lats-IN-1 represents a promising therapeutic strategy for improving outcomes in heart diseases characterized by cardiomyocyte loss. This study highlights the critical role of the Hippo pathway in facilitating cardiac regeneration.
Authors
- Dandan Zhou (ORCID: https://orcid.org/0000-0002-7054-4498)
- Hua Shen (ORCID: https://orcid.org/0000-0002-6250-9377)
- Jinqiang Zhuang
- Yihui Wang (ORCID: https://orcid.org/0000-0001-8477-6145)
- Lin Zhang (ORCID: https://orcid.org/0000-0002-7412-5784)
- Bohan Liu (ORCID: https://orcid.org/0000-0002-4810-8374)
- Qing Wang (ORCID: https://orcid.org/0009-0004-6252-2565)
Institutions
- Shanghai Chest Hospital (CN)
- Chinese PLA General Hospital (CN)
- Shanghai East Hospital (CN)
- Shanghai First People's Hospital (CN)
- Yangzhou Vocational University (CN)
- Yangzhou University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-10-03
- DOI
- https://doi.org/10.3389/fphar.2024.1463465
- Citations
- 3
- Primary Topic
- Hippo pathway signaling and YAP/TAZ
- Type
- article
- Field-Weighted Citation Impact
- 0.98