Association between lipid-lowering agents with intervertebral disc degeneration, sciatica and low back pain: a drug-targeted mendelian randomized study and cross-sectional observation
The results of cross-sectional study suggested that non-use of statins was positively correlated with LBP. The results of Mendelian randomization study suggest that NPC1L1 could lower the risk of developing IVDD by reducing TC, LDL-C, and non-HDL-C levels. Additionally, PCSK9 may reduce the risk of developing sciatica by lowering LDL-C and TC levels. In contrast, HMGCR appears to have no significant effect on IVDD, sciatica, or LBP development. Nonetheless, further research is needed to verify these preliminary results. MST1 warrants further exploration as a potential therapeutic target. It is necessary to do further research to validate these findings.
Authors
- Xinqiao Chu
- Shuo Feng (ORCID: https://orcid.org/0000-0002-1739-6385)
- Yufang Zhang (ORCID: https://orcid.org/0000-0003-1056-788X)
- Qiubai Jin (ORCID: https://orcid.org/0000-0002-5210-7809)
- Ji Zheng (ORCID: https://orcid.org/0000-0002-8783-2146)
- Yaning Biao (ORCID: https://orcid.org/0000-0001-5859-9413)
- Yixin Zhang (ORCID: https://orcid.org/0000-0002-6669-4995)
- Chenxu Liu (ORCID: https://orcid.org/0000-0002-0370-0294)
- Ya Gao (ORCID: https://orcid.org/0000-0002-2672-8898)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Hebei University of Chinese Medicine (CN)
- Guang’anmen Hospital (CN)
Publication Details
- Journal
- Lipids in Health and Disease
- Published
- 2024-10-02
- DOI
- https://doi.org/10.1186/s12944-024-02311-w
- Citations
- 4
- Primary Topic
- Musculoskeletal pain and rehabilitation
- Type
- article
- Field-Weighted Citation Impact
- 1.79
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hebei Province
- China Academy of Chinese Medical Sciences