A randomized trial of pharmacological ascorbate, gemcitabine, and nab-paclitaxel for metastatic pancreatic cancer
P-AscH<sup>-</sup> infusions of 75 g three times weekly in patients with metastatic pancreatic cancer prolongs overall and progression free survival without detriment to quality of life or added toxicity (ClinicalTrials.gov number NCT02905578).
Authors
- Mandana Kamgar (ORCID: https://orcid.org/0000-0001-9364-2712)
- Heather Brown (ORCID: https://orcid.org/0009-0003-5547-9821)
- Daniel Berg (ORCID: https://orcid.org/0000-0002-9181-8902)
- Joseph M. Caster (ORCID: https://orcid.org/0000-0001-6880-6770)
- Chandrikha Chandrasekharan (ORCID: https://orcid.org/0000-0003-2924-2233)
- Barbara Dion
- John M. Buatti (ORCID: https://orcid.org/0000-0001-8499-3721)
- Brett A. Wagner (ORCID: https://orcid.org/0000-0002-0094-7259)
- Kellie L. Bodeker (ORCID: https://orcid.org/0000-0002-8930-2819)
- Saima Sharif (ORCID: https://orcid.org/0000-0002-0478-4442)
- Sandy Vollstedt (ORCID: https://orcid.org/0009-0001-6612-8803)
- Meghan L. Chandler (ORCID: https://orcid.org/0009-0009-7120-0572)
- Garry R. Buettner (ORCID: https://orcid.org/0000-0002-5594-1903)
- Naomi Fei
- Joseph J. Cullen (ORCID: https://orcid.org/0000-0002-2222-1328)
- Bruce A. Smith (ORCID: https://orcid.org/0000-0003-1250-1710)
- Bryan G. Allen (ORCID: https://orcid.org/0000-0002-4893-7105)
- Amanda C. Lorack (ORCID: https://orcid.org/0009-0004-2309-932X)
- Jared S. Wulfekuhle (ORCID: https://orcid.org/0009-0003-8077-7177)
- Stacy McMichael
Institutions
- University of Iowa (US)
- Medical College of Wisconsin (US)
Publication Details
- Journal
- Redox Biology
- Published
- 2024-10-02
- DOI
- https://doi.org/10.1016/j.redox.2024.103375
- Citations
- 25
- Primary Topic
- Vitamin C and Antioxidants Research
- Type
- article
- Field-Weighted Citation Impact
- 7.74
Funders
- McGuff Pharmaceuticals
- National Institutes of Health
- Holden Comprehensive Cancer Center, University of Iowa
- National Cancer Institute