Uptake of Mesenchymal Stem Cell-Derived Exosomes in Mouse Brain through Intranasal Delivery

Exosomes can enter the brains of adult mice through intranasal administration, but there are differences in the uptake rate among mice of different ages. These findings provide a theoretical basis for the future clinical administration of exosomes for treating brain disorders.

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Publication Details

Journal
Current Drug Delivery
Published
2024-10-02
DOI
https://doi.org/10.2174/0115672018339798240904171503
Primary Topic
Extracellular vesicles in disease
Type
article
Field-Weighted Citation Impact
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article

Uptake of Mesenchymal Stem Cell-Derived Exosomes in Mouse Brain through Intranasal Delivery

Qiguo Xiao, Songbin Liu, Siqi He, Fangfang Lu et al.
Current Drug Delivery
Extracellular vesicles in disease
article

Uptake of Mesenchymal Stem Cell-Derived Exosomes in Mouse Brain through Intranasal Delivery

Qiguo Xiao, Songbin Liu, Siqi He, Fangfang Lu, Zihe Zhang, Wenjun Xu, Weijie Jiang, Jia Zhang, Zhi Wang, Jing Lu
article en

Abstract

Exosomes can enter the brains of adult mice through intranasal administration, but there are differences in the uptake rate among mice of different ages. These findings provide a theoretical basis for the future clinical administration of exosomes for treating brain disorders.

Current Drug DeliveryVol. 22(8)
Gannan Medical University (CN), University of South China (CN)
Good health and well-being
Openalex Percentile: Top 85%
Extracellular vesicles in disease
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