Prenatal and progressive coenzyme Q<sub>10</sub> administration to mitigate muscle dysfunction in mitochondrial disease
Our work uncovered novel aspects of CoQ deficiencies, revealing defects during embryonic development in mammals for the first time. Additionally, we identified the gradual establishment and progression of the deleterious Adck2 mouse phenotype. Importantly, CoQ<sub>10</sub> supplementation demonstrated a protective effect when initiated during development.
Authors
- Jaime J. Carvajal (ORCID: https://orcid.org/0000-0002-7277-0317)
- Plácido Navas (ORCID: https://orcid.org/0000-0002-4115-7966)
- Peter S. Zammit (ORCID: https://orcid.org/0000-0001-9562-3072)
- Cristina Vicente‐García (ORCID: https://orcid.org/0000-0002-7720-9449)
- Juan Diego Hernández‐Camacho (ORCID: https://orcid.org/0000-0001-9726-6726)
- Guillermo López‐Lluch (ORCID: https://orcid.org/0000-0001-9830-8502)
- Daniel J.M. Fernández‐Ayala (ORCID: https://orcid.org/0000-0001-8176-1431)
- Carlos Santos‐Ocaña (ORCID: https://orcid.org/0000-0002-2379-796X)
- Lorena Ardila‐García
- Ana Padilla‐Campos
Institutions
- King's College London (GB)
- Instituto de Salud Carlos III (ES)
- Centre for Biomedical Network Research on Rare Diseases (ES)
- Centro Andaluz de Biología del Desarrollo (ES)
- Universidad Pablo de Olavide (ES)
Publication Details
- Journal
- Journal of Cachexia Sarcopenia and Muscle
- Published
- 2024-10-02
- DOI
- https://doi.org/10.1002/jcsm.13574
- Citations
- 5
- Primary Topic
- Coenzyme Q10 studies and effects
- Type
- article
- Field-Weighted Citation Impact
- 1.17
Funders
- Friends of FSH Research
- Ministerio de Educación, Cultura y Deporte
- Ministerio de Ciencia e Innovación
- Medical Research Council
- Instituto de Salud Carlos III
- European Regional Development Fund
- Consejería de Igualdad, Políticas Sociales y Conciliación, Junta de Andalucía