A simple UFLC method for determination of montelukast in human plasma

In this investigation, an UFLC technique utilizing fluorimetric detection was reported for the analysis of Montelukast (MON) in plasma.The method involves pre-column derivatization using 4-bromomethyl-7methoxycoumarin (BrMmC).The calibration curve linear concentrations from 10 to 1000 ng/mL.The method exhibited an average recovery rate of 95.49%.The newly developed method was effectively utilized to assess the pharmacokinetics of Montelukast (MON) following the administration of a single 10 mg tablet to a healthy male volunteer.