USP29 alleviates the progression of MASLD by stabilizing ACSL5 through K48 deubiquitination
USP29 functions as a novel negative regulator of MASLD by stabilizing ACSL5 to promote FAO. The activation of the USP29-ACSL5 axis may represent a potential therapeutic strategy for MASLD.
Authors
- Zhouxiang Wang
- Yan‐Xiao Ji (ORCID: https://orcid.org/0000-0002-3401-2427)
- Juan‐Juan Qin (ORCID: https://orcid.org/0000-0002-9823-2373)
- Zhi‐Gang She (ORCID: https://orcid.org/0000-0001-9402-4166)
- Hongjie Shi (ORCID: https://orcid.org/0000-0001-9236-2460)
- Peng Zhang (ORCID: https://orcid.org/0000-0002-6129-567X)
- Xiao‐Jing Zhang (ORCID: https://orcid.org/0000-0002-8271-7405)
- Hongliang Li (ORCID: https://orcid.org/0000-0002-9868-0387)
- Tuo Zhang (ORCID: https://orcid.org/0000-0003-3256-5930)
- Song Tian (ORCID: https://orcid.org/0000-0002-7006-6588)
- Jianqing Zhang (ORCID: https://orcid.org/0000-0001-5246-3371)
- Kun Zhu (ORCID: https://orcid.org/0000-0003-4933-8435)
- Qin Fang (ORCID: https://orcid.org/0000-0003-4681-0060)
- Sha Hu
Institutions
- Wuhan University (CN)
- Gannan Medical University (CN)
- Zhongnan Hospital of Wuhan University (CN)
- Renmin Hospital of Wuhan University (CN)
- Taishan Medical University (CN)
Publication Details
- Journal
- Clinical and Molecular Hepatology
- Published
- 2024-10-02
- DOI
- https://doi.org/10.3350/cmh.2024.0478
- Citations
- 13
- Primary Topic
- Ubiquitin and proteasome pathways
- Type
- article
- Field-Weighted Citation Impact
- 3.04
Funders
- National Science Foundation
- National Natural Science Foundation of China
- Wuhan University
- Zhongnan Hospital of Wuhan University