Characterising the expression of the organic cation transporter OCT3 in cutaneous papillomas of dogs
These results show that canine CPs exhibit the expression of surrogate markers that suggest sensitivity to metformin, such as upregulated OCT3 and pS6 expression. Taken together, these findings provide the rationale for the early assessment of the use of metformin as a mechanism-based therapeutic approach for treating canine patients with persistent or multiple CPs.
Authors
- Berenice Liyare Sanz Ressel (ORCID: https://orcid.org/0000-0002-9276-4256)
- Gimena Gómez Castro (ORCID: https://orcid.org/0000-0002-0288-4378)
- Cláudio Gustavo Barbeito (ORCID: https://orcid.org/0000-0001-9459-138X)
- Eduardo Mórtola (ORCID: https://orcid.org/0000-0002-8071-450X)
- Adriana Raquel Massone
Institutions
- Centro Científico Tecnológico - La Plata (AR)
- Universidad Nacional de La Plata (AR)
Publication Details
- Journal
- Veterinary Dermatology
- Published
- 2024-10-02
- DOI
- https://doi.org/10.1111/vde.13302
- Primary Topic
- Cancer and Skin Lesions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Agencia Nacional de Promoción de la Investigación, el Desarrollo Tecnológico y la Innovación