Essential Role of the RIα Subunit of cAMP-Dependent Protein Kinase in Regulating Cardiac Contractility and Heart Failure Development
These results identify RIα as a key negative regulator of cardiac contractile function, arrhythmia, and pathological remodeling.
Authors
- Philippe Matéo (ORCID: https://orcid.org/0009-0005-1631-4615)
- Walma Pereira de Vasconcelos (ORCID: https://orcid.org/0009-0000-2471-8445)
- Matthieu Dessillons
- Saïd Bichali (ORCID: https://orcid.org/0000-0003-2220-6061)
- Susana Gómez (ORCID: https://orcid.org/0000-0002-4890-0548)
- Patrick Lechêne (ORCID: https://orcid.org/0000-0002-9194-0000)
- Marine Gandon-Renard (ORCID: https://orcid.org/0000-0002-4862-036X)
- Constantine A. Stratakis (ORCID: https://orcid.org/0000-0002-4058-5520)
- Françoise Mercier‐Nomé (ORCID: https://orcid.org/0000-0002-9515-7232)
- J.-J. Mercadier (ORCID: https://orcid.org/0000-0002-7398-0201)
- Sarah Arangurem Karam (ORCID: https://orcid.org/0000-0002-3921-0182)
- Ana M. Gómez (ORCID: https://orcid.org/0000-0003-0009-2884)
- Jérôme Leroy (ORCID: https://orcid.org/0000-0001-5168-0606)
- Vincent Algalarrondo (ORCID: https://orcid.org/0000-0001-5971-1235)
- Joffrey Cellier
- Grégoire Vandecasteele (ORCID: https://orcid.org/0000-0002-4046-4171)
- Jean‐Pierre Bénitah (ORCID: https://orcid.org/0000-0002-9866-9081)
- Maya Dia (ORCID: https://orcid.org/0000-0001-6531-9176)
- Rodolphe Fischmeister (ORCID: https://orcid.org/0000-0003-2086-9865)
- Audrey Dubourg (ORCID: https://orcid.org/0000-0002-0213-1261)
- Ibrahim Bedioune
- Aurélien Barthou
- Delphine Mika (ORCID: https://orcid.org/0000-0003-2895-7173)
- Audrey Varin (ORCID: https://orcid.org/0009-0000-1709-2333)
Institutions
- National Institutes of Health (US)
- MACOM (United States) (US)
- Inserm (FR)
- Université Paris-Saclay (FR)
- Elpen Pharmaceutical (Greece) (GR)
- Institut des Sciences des Plantes de Paris Saclay (FR)
- FORTH Institute of Molecular Biology and Biotechnology (GR)
- Hôpital Xavier Arnozan (FR)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (US)
Publication Details
- Journal
- Circulation
- Published
- 2024-10-02
- DOI
- https://doi.org/10.1161/circulationaha.124.068858
- Citations
- 5
- Primary Topic
- Cardiac electrophysiology and arrhythmias
- Type
- article
- Field-Weighted Citation Impact
- 2.01
Funders
- Agence Nationale de la Recherche
- Institut National de la Santé et de la Recherche Médicale
- Fondation pour la Recherche Médicale
- Fédération Française de Cardiologie
- Université Paris-Saclay
- Laboratoire d'Excellence en Recherche sur le Médicament et l'Innovation Thérapeutique
- National Institutes of Health