<i>LRP1</i> Repression by SNAIL Results in ECM Remodeling in Genetic Risk for Vascular Diseases
Our findings support allele-specific <i>LRP1</i> expression repression by the endothelial-to-mesenchymal transition regulator SNAIL. We propose decreased <i>LRP1</i> expression in smooth muscle cells to remodel the extracellular matrix enhanced by TGF-β as a potential mechanism of this pleiotropic locus for vascular diseases.
Authors
- Charlène Jouve (ORCID: https://orcid.org/0000-0002-5792-4621)
- Adrien Georges (ORCID: https://orcid.org/0000-0003-4208-2393)
- Yingwei Liu (ORCID: https://orcid.org/0000-0001-7635-0566)
- Nabila Bouatia‐Naji (ORCID: https://orcid.org/0000-0001-5424-2134)
- Jean‐Sébastien Hulot (ORCID: https://orcid.org/0000-0001-5463-6117)
- Lu Liu (ORCID: https://orcid.org/0000-0002-5762-1751)
- Joséphine Henry (ORCID: https://orcid.org/0000-0002-3343-4505)
Institutions
- Inserm (FR)
- Université Paris Cité (FR)
- Paris Cardiovascular Research Center (FR)
Publication Details
- Journal
- Circulation Research
- Published
- 2024-10-02
- DOI
- https://doi.org/10.1161/circresaha.124.325269
- Citations
- 11
- Primary Topic
- Congenital Heart Disease Studies
- Type
- article
- Field-Weighted Citation Impact
- 4.25
Funders
- Fédération Française de Cardiologie
- Société Française de Cardiologie
- National Institutes of Health
- National Heart, Lung, and Blood Institute
- National Institute of Mental Health
- NIH Office of the Director
- National Cancer Institute
- Common Fund