Loss of EMI1 compromises chromosome stability and is associated with cellular transformation in colonic epithelial cell contexts
This study determined that reduced EMI1 expression induces CIN and promotes cellular transformation, which is consistent with a role in early CRC development.
Authors
- Kirk J. McManus (ORCID: https://orcid.org/0000-0003-0081-8737)
- Zelda Lichtensztejn (ORCID: https://orcid.org/0000-0002-0280-2555)
- Nicole M. Neudorf (ORCID: https://orcid.org/0000-0003-0955-5347)
- Rubi Campos Gudiño (ORCID: https://orcid.org/0000-0002-1152-8885)
- Demi Andromidas
Institutions
- CancerCare Manitoba (CA)
- Research Institute in Oncology and Hematology (CA)
- University of Manitoba (CA)
Publication Details
- Journal
- British Journal of Cancer
- Published
- 2024-10-02
- DOI
- https://doi.org/10.1038/s41416-024-02855-9
- Citations
- 2
- Primary Topic
- RNA and protein synthesis mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.47
Funders
- Research Manitoba
- Cancer Research Society
- CancerCare Manitoba Foundation
- Strong
- Natural Sciences and Engineering Research Council of Canada