Long-Term Outcomes After Septal Reduction Therapies in Obstructive Hypertrophic Cardiomyopathy: Insights From the SHARE Registry
Successful short- and long-term relief of outflow tract obstruction was observed in experienced multidisciplinary HCM centers. A subset of patients progressed to develop HF, but event-free survival at 10 years was 83% and ventricular arrhythmias were rare. Older age, female sex, and SRT during childhood were associated with a greater risk of developing HF.
Authors
- Nosheen Reza (ORCID: https://orcid.org/0000-0002-2942-3731)
- John C. Stendahl (ORCID: https://orcid.org/0000-0002-1568-9280)
- Michelle Michels (ORCID: https://orcid.org/0000-0001-6432-0431)
- Ioannis Skalidis (ORCID: https://orcid.org/0000-0002-4374-0389)
- James S. Ware (ORCID: https://orcid.org/0000-0002-6110-5880)
- Alejandro De Feria Alsina
- Sara Saberi (ORCID: https://orcid.org/0000-0003-4473-6725)
- Iacopo Olivotto (ORCID: https://orcid.org/0000-0003-1751-9266)
- Joseph William Rossano (ORCID: https://orcid.org/0000-0002-8284-0673)
- ANJALI TIKU OWENS (ORCID: https://orcid.org/0000-0002-9669-8495)
- Rachel J. Lampert (ORCID: https://orcid.org/0000-0003-3313-0939)
- Ashwin S. Nathan (ORCID: https://orcid.org/0000-0002-7227-6423)
- Victoria Nicole Parikh (ORCID: https://orcid.org/0000-0002-5138-5559)
- Matthew T. Wheeler (ORCID: https://orcid.org/0000-0001-8721-3022)
- Kimberly Y. Lin (ORCID: https://orcid.org/0000-0003-1582-9797)
- Niccolò Maurizi (ORCID: https://orcid.org/0000-0001-5819-204X)
- Jodie Ingles (ORCID: https://orcid.org/0000-0002-4846-7676)
- Dominic James Abrams (ORCID: https://orcid.org/0000-0001-5266-2805)
- Adam S. Helms (ORCID: https://orcid.org/0000-0002-0234-6430)
- Euan Angus Ashley (ORCID: https://orcid.org/0000-0001-9418-9577)
- Sharlene M. Day (ORCID: https://orcid.org/0000-0001-9802-7188)
- Thomas D. Ryan (ORCID: https://orcid.org/0000-0003-4237-576X)
- Mark W. W. Russell (ORCID: https://orcid.org/0000-0003-4855-9260)
- Carlo Fumagalli (ORCID: https://orcid.org/0000-0001-7963-5049)
- Carolyn Ho
- Brian Clagget
- Panagiotis Anthiochos
- Christopher Scemsarian
- Neal Lakdwala
Institutions
- Brigham and Women's Hospital (US)
- Cincinnati Children's Hospital Medical Center (US)
- Boston Children's Hospital (US)
- The University of Sydney (AU)
- Children's Hospital of Philadelphia (US)
- Harvard University (US)
- Garvan Institute of Medical Research (AU)
- University of Michigan (US)
- Royal Prince Alfred Hospital (AU)
- Hospital of the University of Pennsylvania (US)
- Centenary Institute (AU)
- Erasmus MC (NL)
- Yale University (US)
- Lung Institute (US)
- Cancer Research And Biostatistics (US)
- Meyer Children's Hospital (IT)
- Michigan Medicine (US)
- Azienda Ospedaliero-Universitaria Careggi (IT)
- University of Campania "Luigi Vanvitelli" (IT)
- Cardiovascular Research Center (BR)
- University of Pennsylvania (US)
- Erasmus University Rotterdam (NL)
- University of Lausanne (CH)
Publication Details
- Journal
- Circulation
- Published
- 2024-10-02
- DOI
- https://doi.org/10.1161/circulationaha.124.069378
- Citations
- 38
- Primary Topic
- Cardiomyopathy and Myosin Studies
- Type
- article
- Field-Weighted Citation Impact
- 15.28
Funders
- American Heart Association
- Bristol-Myers Squibb
- Pfizer
- Alexion Pharmaceuticals
- Boston Scientific Corporation
- Wellcome Trust
- Cytokinetics
- Amicus Therapeutics
- National Institutes of Health
- Medical Research Council
- National Health and Medical Research Council
- National Heart, Lung, and Blood Institute