Definitions of white matter hyperintensity change: impact on estimates of progression and regression
Different WMH change definitions cause big differences in how participants are categorised; additionally, non-normal WMH distribution precludes use of some definitions. Consistent use of an appropriate definition would facilitate data comparisons, particularly in clinical trials of potential WMH treatments.
Authors
- Susana Muñoz Maniega (ORCID: https://orcid.org/0000-0001-5185-6384)
- Joanna Marguerite Wardlaw (ORCID: https://orcid.org/0000-0002-9812-6642)
- Angela C.C. Jochems (ORCID: https://orcid.org/0000-0001-7392-3066)
- Fergus Doubal (ORCID: https://orcid.org/0000-0002-2769-3148)
- Donna McIntyre
- Michael J. Thrippleton (ORCID: https://orcid.org/0000-0001-7858-9917)
- Úna Clancy (ORCID: https://orcid.org/0000-0002-8062-7537)
- Daniela Jaime García (ORCID: https://orcid.org/0000-0002-9457-9855)
- Francesca M. Chappell (ORCID: https://orcid.org/0000-0002-7742-1757)
- Carmen Arteaga (ORCID: https://orcid.org/0000-0003-2424-7123)
- Gayle Barclay (ORCID: https://orcid.org/0009-0001-2417-2750)
- Iona Gerrish
- Stewart Wiseman (ORCID: https://orcid.org/0000-0001-6739-5797)
- Michael Stringer (ORCID: https://orcid.org/0000-0002-3811-4439)
- Charlotte Jardine (ORCID: https://orcid.org/0009-0001-3732-4135)
- Maria del C. Valdés Hernández
Institutions
- UK Dementia Research Institute (GB)
- University of Edinburgh (GB)
Publication Details
- Journal
- Stroke and Vascular Neurology
- Published
- 2024-10-02
- DOI
- https://doi.org/10.1136/svn-2024-003300
- Citations
- 5
- Primary Topic
- Acute Ischemic Stroke Management
- Type
- article
- Field-Weighted Citation Impact
- 1.93
Funders
- Wellcome Trust
- Alzheimer's Society
- British Heart Foundation
- Stroke Association
- Fondation Leducq
- Consejo Nacional de Ciencia y Tecnología
- UK Dementia Research Institute
- Directorate for Biological Sciences
- Medical Research Council
- Biotechnology and Biological Sciences Research Council
- Economic and Social Research Council
- College of Medicine and Veterinary Medicine, University of Edinburgh