Three-outcome designs for external pilot trials with progression criteria
The proposed three-outcome framework provides a way to optimise pilot trial progression criteria and sample size in a way that leads to desired operating characteristics. It can be applied whether or not an adjustment following the pilot trial is anticipated, but will generally lead to larger sample size requirements than simpler two-outcome alternatives.
Authors
- Duncan T. Wilson (ORCID: https://orcid.org/0000-0001-7949-8718)
- Sarah Brown (ORCID: https://orcid.org/0000-0002-7975-7537)
- Eleanor Hudson (ORCID: https://orcid.org/0000-0001-8758-7163)
Institutions
- University of Leeds (GB)
Publication Details
- Journal
- BMC Medical Research Methodology
- Published
- 2024-10-02
- DOI
- https://doi.org/10.1186/s12874-024-02351-x
- Citations
- 1
- Primary Topic
- Statistical Methods in Clinical Trials
- Type
- article
- Field-Weighted Citation Impact
- 1.42
Funders
- Medical Research Council