Proteomic biomarkers of long-term lung function decline in textile workers: a 35-year longitudinal study
We performed a large-scale proteomic study of the longest-follow-up pulmonary function cohort of textile workers to date. We discovered multiple novel proteins associated with long-term decline of FEV<sub>1</sub> that have potential for identifying new biomarkers associated with long-term lung function decline among occupational populations, and may identify individuals at risk, as well as potential pharmaceutical targets for early intervention.
Authors
- Liangmin Wei
- Ruyang Zhang (ORCID: https://orcid.org/0000-0003-3861-4297)
- Longyao Zhang (ORCID: https://orcid.org/0000-0002-0687-8397)
- Yongyue Wei (ORCID: https://orcid.org/0000-0002-1132-1796)
- Li Su (ORCID: https://orcid.org/0000-0002-1435-9669)
- Fangfang Chen (ORCID: https://orcid.org/0000-0002-0854-1667)
- Fengying Zhang (ORCID: https://orcid.org/0000-0002-8343-9427)
- Hantao Wang (ORCID: https://orcid.org/0009-0002-0443-8424)
- Mengsheng Zhao
- Jingqing Hang
- D.C. Christiani
Institutions
- Nanjing University of Chinese Medicine (CN)
- Harvard University (US)
- Peking University (CN)
- Massachusetts General Hospital (US)
- Ministry of Education (RO)
- Central Hospital of Putuo District (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Journal of Exposure Science & Environmental Epidemiology
- Published
- 2024-10-02
- DOI
- https://doi.org/10.1038/s41370-024-00721-7
- Citations
- 2
- Primary Topic
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Type
- article
- Field-Weighted Citation Impact
- 0.84
Funders
- National Natural Science Foundation of China
- National Institute for Occupational Safety and Health