An Injectable Photothermal-Fusing Hydrogel: Achieving Temperature-Controllable Mild Photothermal Therapy to Reverse Chemotherapy-Induced Immune Tolerance
Mild photothermal therapy (M-PTT) can induce immunogenic cell death (ICD) to reverse the immune tolerance caused by low-dose chemotherapy. However, it still needs convenient strategies to control temperature during M-PTT. In this work, the phase change material lauric acid (LA, melting point 43 °C) was introduced to construct nanoparticles loaded with deferoxamine mesylate (DFO) and cisplatin (CDDP), which were mixed into a supramolecular hydrogel formed by polyvinylpyrrolidone (PVP)/tannic acid (TA)/Fe<sup>3+</sup> to obtain FeTP@DLD/DLC. When the temperature reached 43 °C under laser irradiation, DFO was released from melted LA and destroyed the interaction between Fe<sup>3+</sup> and TA to cut off the temperature increase, achieving a "photothermal fusing effect". Meanwhile, CDDP was released for low-dose chemotherapy, while the resulting immune tolerance was reversed by M-PTT-induced ICD. Finally, through a single administration, FeTP@DLD/DLC-mediated M-PTT synergized with chemotherapy achieved a potent antitumor effect. This work provided a convenient solution for the revitalization of these traditional antitumor therapies.
Authors
- Tong Li (ORCID: https://orcid.org/0000-0001-7331-384X)
- Qiannan Cao
- Xuan Pang (ORCID: https://orcid.org/0000-0003-3293-832X)
- Ludan Shang
- Xuesi Chen (ORCID: https://orcid.org/0000-0003-3542-9256)
- Yumeng Xing (ORCID: https://orcid.org/0000-0001-7791-2313)
- Xiaoya Guo
- Fei Li (ORCID: https://orcid.org/0000-0002-5306-4185)
- Jie Chen (ORCID: https://orcid.org/0000-0003-1945-0047)
- Yanhui Li (ORCID: https://orcid.org/0000-0002-5700-3953)
- Meng Meng (ORCID: https://orcid.org/0000-0002-9715-6292)
- Huayu Tian (ORCID: https://orcid.org/0000-0002-2482-3744)
- Jiayan Wu (ORCID: https://orcid.org/0000-0002-3695-045X)
- Zhaoyuan Tu (ORCID: https://orcid.org/0009-0000-2300-2437)
- Kai Hao (ORCID: https://orcid.org/0009-0007-1855-9725)
- Ruiying Wu
- Penghan Yue
- Keyang Li (ORCID: https://orcid.org/0000-0001-7065-039X)
Institutions
- University of Science and Technology of China (CN)
- Xiamen University (CN)
- Chinese Academy of Sciences (CN)
- Changchun Institute of Applied Chemistry (CN)
- Collaborative Innovation Center of Chemistry for Energy Materials (CN)
- Xiamen University of Technology (CN)
Publication Details
- Journal
- Nano Letters
- Published
- 2024-10-02
- DOI
- https://doi.org/10.1021/acs.nanolett.4c03766
- Citations
- 5
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 0.92
Funders
- National Natural Science Foundation of China
- Xiamen University of Technology
- National Key Research and Development Program of China