Molecular determinants of resurgent sodium currents mediated by Navβ4 peptide and A-type FHFs
Cryo-EM structures reveal that the side chains of the critical residues project into the VGSC channel pore. Our findings provide additional evidence that Navβ4 peptide and A-type FHFs function as open-channel pore blockers and highlight channel inner pore region as a hotspot for development of novel agents targeting <i>I<sub>NaR</sub></i> .
Authors
- Jingyu Xiao (ORCID: https://orcid.org/0000-0002-6961-7397)
- Yucheng Xiao (ORCID: https://orcid.org/0000-0002-0298-7158)
- Theodore Cummins (ORCID: https://orcid.org/0000-0001-9509-6380)
- Yanling Pan (ORCID: https://orcid.org/0000-0002-0915-2639)
Institutions
- University of Indianapolis (US)
- Purdue University West Lafayette (US)
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Frontiers in Molecular Neuroscience
- Published
- 2024-10-02
- DOI
- https://doi.org/10.3389/fnmol.2024.1433981
- Citations
- 3
- Primary Topic
- Ion channel regulation and function
- Type
- article
- Field-Weighted Citation Impact
- 0.70
Funders
- Craig H. Neilsen Foundation
- Indiana State Department of Health
- National Institutes of Health