Tetrasubstituted Chromanone Synthesis by a Tandem Oxa‐Michael/Michael Addition Reaction of 2‐Hydroxyacetophenones and Alkynyl Nitriles
Abstract An efficient transition metal‐free approach for the synthesis of chroman‐4‐ones via double conjugate addition of 2‐hydroxyacetophenones on alkynyl nitriles utilizing NaH as a base has been realized. This operationally simple protocol offers library of 4‐chromanones in moderate to good yields.
Authors
- Avijit Goswami (ORCID: https://orcid.org/0000-0003-2798-1956)
- Madan Kumar
- Chandresh Kumari
- Narendra Prasad Sahoo
Institutions
- Indian Institute of Technology Ropar (IN)
Publication Details
- Journal
- European Journal of Organic Chemistry
- Published
- 2024-10-02
- DOI
- https://doi.org/10.1002/ejoc.202401061
- Citations
- 1
- Primary Topic
- Synthesis of Organic Compounds
- Type
- article
- Field-Weighted Citation Impact
- 0.45