Harnessing gut microbiota for longevity: Insights into mechanisms and genetic manipulation
The gut microbiota is pivotal in maintaining health, with most microorganisms being beneficial, except for a few pathogens. Emerging evidence suggests a link between the gut microbiome and aging, hinting at its potential role in longevity. However, understanding the relationship is challenging due to the microbiota's complexity. This perspective summarizes the mechanisms by which gut microbes regulate host lifespan and explores genetic manipulation strategies to promote healthy aging in the elderly.
Authors
- Zuobin Zhu (ORCID: https://orcid.org/0000-0003-1022-5943)
- Ziling Yang (ORCID: https://orcid.org/0009-0005-9876-8724)
- Yalun Wu (ORCID: https://orcid.org/0009-0004-0352-5934)
- Peng Shi (ORCID: https://orcid.org/0000-0002-4075-4902)
- Simin Xu (ORCID: https://orcid.org/0000-0001-6839-9642)
- Ying Li (ORCID: https://orcid.org/0000-0002-1293-6610)
- Liying Wang
Institutions
- National University of Singapore (SG)
- Xuzhou Medical College (CN)
Publication Details
- Journal
- iMetaOmics.
- Published
- 2024-10-02
- DOI
- https://doi.org/10.1002/imo2.36
- Citations
- 5
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 1.17
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Jiangsu Province