Therapeutic Potential of Mesenchymal Stem Cell–Derived Extracellular Vesicles Carrying MicroRNAs for Modulating Autophagy and Cellular Degeneration in Intervertebral Disc Degeneration
MSC-EVs carrying specific miRNAs can effectively modulate gene expression, reduce degenerative processes, and promote cellular proliferation in IDD, indicating a promising therapeutic strategy for treating IDD and potentially other degenerative diseases. Further investigations are warranted to explore MSC-EV applications in regenerative medicine.
Authors
- Jianhang Jiao
- Minfei Wu (ORCID: https://orcid.org/0000-0001-8230-3774)
- Mufeng Li
- Tong Yu (ORCID: https://orcid.org/0000-0001-6644-4745)
- Weibo Jiang (ORCID: https://orcid.org/0000-0003-2258-6826)
- Su Pan
- Linfeng Wang (ORCID: https://orcid.org/0000-0002-0074-6043)
- Yang Wang (ORCID: https://orcid.org/0000-0001-5705-8244)
- Zhonghan Wang (ORCID: https://orcid.org/0000-0001-8782-3349)
Institutions
- Thales (Australia) (AU)
- Second Affiliated Hospital of Jilin University (CN)
Publication Details
- Journal
- Spine
- Published
- 2024-10-02
- DOI
- https://doi.org/10.1097/brs.0000000000005167
- Citations
- 5
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 2.12