Hypoglycemic drugs, circulating inflammatory proteins, and gallbladder diseases: A mediation mendelian randomization study
Metformin plays a protective role in cholelithiasis, while GLP-1RA have a harmful effect on the risk of cholecystitis. Metformin may reduce the risk of cholelithiasis by modulating the levels of Neurotrophin-3 (NT-3) and Interleukin-10 receptor subunit beta (IL-10RB). Further clinical and mechanistic studies are required to confirm these findings.
Authors
- Jianbo Zhou (ORCID: https://orcid.org/0000-0003-2507-9192)
- Xingyao Tang (ORCID: https://orcid.org/0009-0003-6947-5661)
- Ziqi Wang (ORCID: https://orcid.org/0000-0002-4235-8073)
- Jinyan Zhang
Institutions
- Beijing Tongren Hospital (CN)
- Capital Medical University (CN)
Publication Details
- Journal
- Diabetes Research and Clinical Practice
- Published
- 2024-10-02
- DOI
- https://doi.org/10.1016/j.diabres.2024.111882
- Citations
- 5
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 2.75
Funders
- National Natural Science Foundation of China