Interactive effect of diabetes mellitus and subclinical MRI markers of cerebrovascular disease on cognitive decline and incident dementia: a memory-clinic study
The effect of diabetes on cognitive decline is contingent upon the presence of WMHs and independent of Alzheimer's pathology. This finding raises the possibility of utilizing WMHs as an imaging biomarker to identify diabetic subgroup at greater risk of developing cognitive impairment. Furthermore, therapeutic interventions targeting WMHs may prevent cognitive deterioration in older adults with diabetes.
Authors
- Caroline Robert (ORCID: https://orcid.org/0000-0002-0381-593X)
- Narayanaswamy Venketasubramanian (ORCID: https://orcid.org/0000-0003-3593-6362)
- Joyce Ruifen Chong (ORCID: https://orcid.org/0000-0002-2869-0096)
- Saima Hilal (ORCID: https://orcid.org/0000-0001-5434-5635)
- Mitchell K.P. Lai (ORCID: https://orcid.org/0000-0001-7685-1424)
- Christopher Chen (ORCID: https://orcid.org/0000-0001-5130-0079)
- Jiangbo Cui (ORCID: https://orcid.org/0000-0003-4403-4248)
- Boon Yeow Tan
- Eddie Chong Jun Yi
- Chia May Teh
Institutions
- National University of Singapore (SG)
- Raffles Institution (SG)
- National University Health System (SG)
- St Luke's Hospital (SG)
Publication Details
- Journal
- Alzheimer s Research & Therapy
- Published
- 2024-10-03
- DOI
- https://doi.org/10.1186/s13195-024-01577-7
- Citations
- 4
- Primary Topic
- Neurological Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.99
Funders
- Medical Research Council
- National Medical Research Council