Race- associated molecular differences in uterine serous carcinoma

Black patients constituted 44% of patients with USC in our study and had an increased frequency of <i>CCNE1</i> amplification. Patients whose tumors harbored <i>CCNE1</i> amplification had shorter overall survival. Identifying actionable mutations in this high unmet need population is crucial to improving outcomes among Black patients with uterine malignancy. Development of new targeted-therapies will need to keep these alterations at the forefront as trials are being designed.