Investigation of the anti-inflammatory, anti-pruritic, and analgesic effects of sophocarpine inhibiting TRP channels in a mouse model of inflammatory itch and pain
Sophocarpine is a potential competitive inhibitor of TRPA1 and TRPV1 channels eliciting strong anti-inflammatory, anti-pruritic, and analgesic effects, suggesting its significant therapeutic potential in treating diseases with inflammatory itch and pain.
Authors
- Ranjing Wang
- Hong Nie (ORCID: https://orcid.org/0000-0002-7409-4260)
- Hekun Zeng (ORCID: https://orcid.org/0000-0002-6644-7353)
- Dan Zhou (ORCID: https://orcid.org/0000-0003-0103-3691)
- Alexei Verkhratsky (ORCID: https://orcid.org/0000-0003-2592-9898)
- Zhe Zhang (ORCID: https://orcid.org/0000-0002-7209-614X)
Institutions
- Ikerbasque (ES)
- Ministry of Education (TH)
Publication Details
- Journal
- Journal of Ethnopharmacology
- Published
- 2024-10-02
- DOI
- https://doi.org/10.1016/j.jep.2024.118882
- Citations
- 6
- Primary Topic
- Ion Channels and Receptors
- Type
- article
- Field-Weighted Citation Impact
- 2.17
Funders
- National Natural Science Foundation of China