Marked variation in disease acuity and outcomes on the liver transplant waiting list by sociodemographic characteristics

Understanding the association of social determinants of health with liver transplant listing and waitlist outcomes can inform health care policy and interventions aimed at improving access to care. We analyzed the Scientific Registry of Transplant Recipients database merged with the Social Deprivation Index (SDI) to evaluate if the area of residence is associated with the Model for End-Stage Liver Disease incorporating sodium (MELD-Na) at the time of waitlist placement and outcomes following waitlisting, and if this varied based on sociodemographic variables. Compared to candidates residing in areas of low SDI, those residing in areas of high SDI (most socioeconomic disadvantage) had 11% higher adjusted likelihood (aOR [95% CI] = 1.11 [CI 1.05,1.17]) of being listed for transplant with a MELD-Na score ≥30; this was not statistically significant when also adjusted for race/ethnicity (aOR = 1.02 [0.97,1.08]). When stratified by race/ethnicity, residing in an area of high SDI was associated with a MELD-Na score ≥30 at the time of waitlisting among Hispanic White candidates (aOR = 1.24, 95% CI: 1.04, 1.49). Candidates residing in areas of high SDI had an 8% lower chance (adjusted hazard ratio [aHR] = 0.92 [0.88,0.96]) of undergoing a liver transplant, a 6% higher risk of death (aHR = 1.06 [1.002,1.13]), and a 20% higher risk (aHR = 1.20 [1.13,1.28]) of removal on the waitlist independent of race, ethnicity, insurance status, or sex. In the United States, residence in areas of high socioeconomic disadvantage is significantly associated with higher MELD-Na at the time of waitlisting among Hispanic White candidates. In addition, residence in areas of high socioeconomic disadvantage was associated with a higher risk of death or removal from the waitlist and lower chances of receiving a liver transplant after waitlist placement, particularly among Non-Hispanic White candidates and older candidates.