Genomic analysis of an acute gastroenteritis outbreak caused by rotavirus C in Hebei, China
Rotavirus group C is an important cause of sporadic cases and outbreaks of gastroenteritis worldwide. Whole-Genome sequences of human rotavirus C (RVC) in public databases are limited. We performed genome sequencing to analyze a RVC outbreak of acute gastroenteritis in China. Samples from 22 patients were screened for pathogens using RT-PCR, and six samples were positive for rotavirus. Whole-Genome sequencing analysis showed that the outbreak strain SJZ217 belongs to the G4-P[2]-I2-R2-C2-M3-A2-N2-T2-E2-H2 genotype and shares almost identical genomic sequences with Chungnam isolated in Korea. Phylogenetic analysis revealed strain SJZ217 also fell into a cluster with rotavirus C strains from Japan and Europe. Reassortment in the VP4 fragment was observed. These results helped to understand the genetic diversity and possible spread of RVC strains.
Authors
- Peihan Li
- Hongbin Song (ORCID: https://orcid.org/0000-0002-2781-3031)
- Chaojie Yang (ORCID: https://orcid.org/0000-0001-6782-1389)
- Lang Yang (ORCID: https://orcid.org/0000-0002-5234-7394)
- Jinhui Li (ORCID: https://orcid.org/0000-0002-2572-3454)
- Yun Wang (ORCID: https://orcid.org/0000-0002-2201-9277)
- Peng Li (ORCID: https://orcid.org/0000-0002-0849-5955)
- Shaofu Qiu (ORCID: https://orcid.org/0000-0001-5070-9294)
- Kaiying Wang (ORCID: https://orcid.org/0000-0001-7170-2091)
- Leili Jia
Institutions
- Chinese Center For Disease Control and Prevention (CN)
- Beijing Fengtai Disease Prevention and Control Center (CN)
- Tianjin Centers for Disease Control and Prevention (CN)
Publication Details
- Journal
- Virology Journal
- Published
- 2024-10-02
- DOI
- https://doi.org/10.1186/s12985-024-02486-9
- Citations
- 3
- Primary Topic
- Viral gastroenteritis research and epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 1.17
Funders
- National Science and Technology Major Project
- National Key Research and Development Program of China