Suspected Postpartum Depression Revealed to be CSF1R-Related Leukoencephalopathy: A Case Report
This case report is consistent with evidence that PPD may have organic causes in some cases, including CSF1R mutations. Atypical findings such as mild cognitive decline combined with PPD in psychiatric interview may justify brain imaging to avoid misdiagnosis, since CSF1R-related leukoencephalopathy is probably an under-recognized disease in medical psychiatry. Further investigations are needed to clarify a pathophysiological correlation between CSF1R signaling abnormality and PPD as well as major depression.
Authors
- Shinya Watanabe (ORCID: https://orcid.org/0000-0003-4044-1292)
- Akihiro Mikami
- Ayako Ishikura
- Hisashi Narita (ORCID: https://orcid.org/0000-0003-0700-6600)
- Shuhei Ishikawa (ORCID: https://orcid.org/0000-0002-2404-1945)
- Kazuhiro Horiuchi (ORCID: https://orcid.org/0000-0002-7040-3273)
- Ichiro Kusumi (ORCID: https://orcid.org/0000-0002-8747-5070)
- Soichiro Kimura (ORCID: https://orcid.org/0000-0003-2385-428X)
- Hidenao Sasaki (ORCID: https://orcid.org/0000-0002-5164-942X)
- Masahiko Mikuni
- Sho Masutani
Institutions
- Gunma University (JP)
- Hokkaido University (JP)
- Hokkaido University Hospital (JP)
- Hakodate Central General Hospital (JP)
- Hakodate National Hospital (JP)
Publication Details
- Journal
- Case Reports in Neurology
- Published
- 2024-10-02
- DOI
- https://doi.org/10.1159/000541551
- Citations
- 1
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.33