BACURI BUTTER TOPICAL EMULGEL (PLATONIA INSIGNIS MART.) AND PIROXICAM FOR THE TREATMENT OF ARTHRITIS: PRECLINICAL TRIALS

Introduction: Several studies have focused on the search for pharmacological activities of bacuri butter (Platonia insignis Mart.), given the empirical use in inflammatory diseases. Thus, the aim is to examine the pharmacological activity of bacuri butter topical emulgel and Piroxicam in an experimental arthritis model. The emulgel is feasible regarding the organoleptic characteristics, physicochemistry and validation of methods of epidemiology. Design: preclinical trial, consisting of the topical formulation of bacuri butter and piroxicam (F1) and topical formulation of bacuri butter (F2); held at the Federal University of Piauí (UFPI), Teresina, PI, Brazil; experimental research with data organization in the period from 2021 to 2022. The results obtained were submitted to analysis of variance (ANOVA), followed by Tukey's post-test, with the aid of the statistical software GraphPad Prism 6.0 (GraphPad Software, San Diego, CA, USA). Results: The arthritis protocol was performed by induction of edema in Wistar's paw by carrageenan, monosodium urate salts, prostaglandin and zymosan. The emulgel exhibited selectivity, linearity, accuracy, precision, robustness, systemic and histological toxicity, and evidence of anti-edematogenic activities. Implications: The emulgel has anti-arthritic and anti-inflammatory activities, low cost, easy access, pleasant color and odor, good adhesion, easy delivery process of the active ingredient to the site of pain.